Antidepressant activity of 4-amino-5-(alkyl-, aryl-, heteryl)-1,2,4-triazole-3-thione benzylidene derivatives
نویسندگان
چکیده
منابع مشابه
4-Amino-3-(4-pyridyl)-1,2,4-triazole-5(4H)-thione
In the title mol-ecule, C(7)H(7)N(5)S, the pyridyl and triazole rings form a dihedral angle of 20.07 (6)°. Inter-molecular N-H⋯N hydrogen bonds link the mol-ecules into chains extended in the direction [10]. Further stability is provided by π⋯π stacking inter-actions, indicated by short distances between the centroids of triazole rings [3.480 (5) Å] and pyridyl rings [3.574 (5) Å] of neighbouri...
متن کامل4-Amino-3-phenyl-1H-1,2,4-triazole-5(4H)-thione
In the title compound, C(8)H(8)N(4)S, the planar triazole ring forms a dihedral angle of 13.7 (2)° with the phenyl ring. The crystal structure is stabilized by inter-molecular N-H⋯S hydrogen-bond inter-actions, linking the mol-ecules into chains along the a axis.
متن کاملAntidepressant activity of new 3-amino-5-disubstituted benzylidene-6-methyl-(4H)-pyridazine derivatives.
By the reaction of various amines with 3-chloropyridazines,several minaprine analogues were prepared.Most of them exhibited significant antidepressant activity.Compound 2a antagonizes reserpine action and neuroleptic-induced catalepsy in a dose-dependent manner. Keywords-disubstituted benzylidene pyridazine;3-amino pyridazine derivative,minaprine analogue;antidepressant activity Recently,it was...
متن کاملGreen synthesis and evaluation of 5-(4-aminophenyl)-4-aryl-4H-1, 2, 4-triazole-3-thiol derivatives
The green synthesis of 5-(4-aminophenyl)-4-aryl-4H-1,2,4-triazole-3-thiol was achieved in four steps, In first step, 4-amino benzoic acid refluxed in ethanol along with catalyst Conc. Sulphuric acid to produce ethyl-4-amino benzoate I. Further compound I refluxed with hydrazine hydrate in ethanol to produce 4-amino benzohydrazide II. Compound II refluxed in ethanolic potassium hydroxide with ca...
متن کامل4-[(3-Nitrobenzylidene)amino]-3-(pyridin-4-yl)-1H-1,2,4-triazole-5(4H)-thione
In the title compound, C(14)H(10)N(6)O(2)S, the dihedral angle between the pyridine and triazole rings is 3.21 (10)°. The mol-ecule is significantly twisted about the N(t)-N(b) (t = triazole and b = benzyl-idene) bond [C-N(t)-N(b)=C = 151.64 (17)°]. In the crystal, mol-ecules are linked by weak N-H⋯N hydrogen bonds, generating C(8) chains propagating in [10[Formula: see text]].
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ژورنال
عنوان ژورنال: Current issues in pharmacy and medicine: science and practice
سال: 2018
ISSN: 2409-2932,2306-8094
DOI: 10.14739/2409-2932.2018.3.145228